tailieunhanh - báo cáo hóa học:" Interleukin-6 as an early marker for fat embolism"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Interleukin-6 as an early marker for fat embolism | Journal of Orthopaedic Surgery and Research Research article Interleukin-6 as an early marker for fat embolism R Yoga 1 JC Theis1 M Walton1 and W Sutherland2 BioMed Central Open Access Address Department of Orthopaedic Surgery University of Otago Dunedin New Zealand and 2Department of Medicine University of Otago Dunedin New Zealand Email RYoga JC Theis - M Walton - W Sutherland - Corresponding author Published 13 June 2009 Received 2 February 2009 Journal of Orthopaedic Surgery and Research 2009 4 18 doi l749-799X-4-l 8 Accepted 13 June 2009 This article is available from http content 4 l 18 2009 Raj et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Fat Embolism is a complication of long bone fractures intramedullary fixation and joint arthroplasty. It may progress to fat embolism syndrome which is rare but involves significant morbidity and can occasionally be fatal. Fat Embolism can be detected at the time of embolization by transoesophageal echocardiography or atrial blood sampling. Later a combination of clinical signs and symptoms will point towards fat embolism but there is no specific test to confirm the diagnosis. We investigated serum Interleukin-6 IL-6 as a possible early marker for fat embolism. Methods An animal study was conducted to simulate a hip replacement in 3l adult male Sprague Dawley rats. The procedure was performed under general anesthesia and the animals divided into 3 groups control uncemented and cemented. Following surgery and recovery from anaesthesia the rats allowed to freely mobilize in their cages. Blood was taken before surgery and at 6 .