tailieunhanh - báo cáo hóa học:" Proliferating and differentiating effects of three different growth factors on pluripotent mesenchymal cells and osteoblast like cells"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Proliferating and differentiating effects of three different growth factors on pluripotent mesenchymal cells and osteoblast like cells | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access Proliferating and differentiating effects of three different growth factors on pluripotent mesenchymal cells and osteoblast like cells Britt Wildemann 1 2 Nicole Burkhardt1 Marc Luebberstedt1 Thomas Vordemvenne3 and Gerhard Schmidmaier1 2 Address 1Center for Musculoskeletal Surgery Charite-Universitatsmedizin Berlin Germany 2Berlin-Brandenburg Center for Regenerative Therapies Berlin Germany and 3Dept. Trauma Hand and Reconstructive Surgery University Hospital Muenster Germany Email Britt Wildemann - Nicole Burkhardt - Marc Luebberstedt - Thomas Vordemvenne - vordemv@ Gerhard Schmidmaier - Corresponding author Published 20 December 2007 Received 17 July 2007 Journal of Orthopaedic Surgery and Research 2007 2 27 doi 1749-799X-2-27 Accepted 20 December 2007 This article is available from http content 2 1 27 2007 Wildemann et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Growth factors are in clinical use to stimulate bone growth and regeneration. BMP-2 is used in long bone and spinal surgery PDGFbb for the treatment of periodontal defects and children with growth hormone receptor deficiency are treated with IGF-I. Aim of the present study was the comparative analysis of the effect of these growth factors released from a local drug delivery system on cells of the osteogenic lineage at differing differentiation stages. The experiments with the mesenchymal cell line C2C12 revealed a proliferating effect of all three growth factors and a differentiating effect of BMP-2 with