tailieunhanh - báo cáo khoa học: " Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Expressions of COX-2 and VEGF-C in gastric cancer: correlations with lymphangiogenesis and prognostic implications | Gou et al. Journal of Experimental Clinical Cancer Research 2011 30 14 http content 30 1 14 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Expressions of COX-2 and VEGF-C in gastric cancer correlations with lymphangiogenesis and prognostic implications 1t - z l z-l 2t 1 1 1 P s z 1 1 Hong-Feng Gou Xin-Chuan Chen Jiang Zhu Ming Jiang Yu Yang Dan Cao Mei Hou Abstract Background Cyclooxygenase-2 COX-2 has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C VEGF-C in breast and lung cancer. However the impact of COX-2 on lymphangiogenesis of gastric cancer remains unclear. This study aims to test the expression of COX-2 and VEGF-C in human gastric cancer and to analyze the correlation with lymphatic vessel density LVD clinicopathologic features and survival prognosis. Methods Using immunohistochemistry COX-2 VEGF-C and level of LVD were analyzed in 56 R0-resected primary gastric adenocarcinomas while paracancerous normal mucosal tissues were also collected as control from 25 concurrent patients. The relationships among COX-2 and VEGF-C expression LVD and clinicopathologic parameters were analyzed. The correlations of COX-2 VEGF-C and level of LVD with patient prognosis were also evaluated by univariate tests and multivariate Cox regression. Results The expression rates of COX-2 and VEGF-C were and respectively in gastric carcinoma. Peritumoral LVD was significantly higher than that in both normal and intratumoral tissue P . It was significantly correlated with lymph node metastasis and invasion depth P P . VEGF-C was significantly associated with peritumoral LVD r P . However COX-2 was not correlated with VEGF-C r P or LVD r P . Univariate analysis showed that survival time was impaired by higher COX-2 expression and higher peritumoral LVD. Multivariate survival analysis showed that age COX-2 expression and .