tailieunhanh - báo cáo khoa học: " Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center | Fabi et al. Journal of Experimental Clinical Cancer Research 2011 30 10 http content 30 1 10 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Brain metastases from solid tumors disease outcome according to type of treatment and therapeutic resources of the treating center 1 1 1 2 1 3 4 Alessandra Fabi Alessandra Felici Giulio Metro Alessandra Mirri Emilio Bria Stefano Telera Luca Moscetti l l i Hcil nna l m D iccill 1 I Tivìvcibbo 5 i nci lofn6 Anidroo Doi Cl7 K lojccfiici7 A fit Cl fid I Cl iHiri8 Michelangelo Russillo Gaetano Lanzetta Giovanni Mansueto Andrea Pace Marta Maschio Antonello Vidiri Isabella Sperduti9 Francesco Cognetti1 Carmine M Carapella3 Abstract Background To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases BMs and to correlate disease outcome with type of treatment and therapeutic resources available at the treating center. Methods Four Cancer centres participated to the survey. Data were collected through a questionnaire filled in by one physician for each centre. Results Clinical data regarding 290 cancer patients with BMs from solid tumors were collected. Median age was 59 and 59 of patients had 3 brain metastases. A local approach surgery and stereotactic radiosurgery was adopted in 31 of patients. The local approach demonstrated to be superior in terms of survival compared to the regional systemic approach whole brain radiotherapy and chemotherapy p .0001 for survival at 2 years . In the multivariate analysis local treatment was an independent prognostic factor for survival. When patients were divided into 2 groups whether they were treated in centers where local approaches were available or not group A vs group B respectively 58 of patients with 3 BMs in both cohorts more patients in group A received local strategies although no difference in time to brain progression at 1 year was observed between the two groups of patients. Conclusions In .