tailieunhanh - báo cáo khoa học: " Stem cells in clinical practice: applications and warnings"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Stem cells in clinical practice: applications and warnings | Lodi et al. Journal of Experimental Clinical Cancer Research 2011 30 9 http content 30 1 9 Journal of Experimental Clinical Cancer Research REVIEW Open Access Stem cells in clinical practice applications and warnings Daniele Lodi1 Tommaso Iannitti2 Beniamino Palmieri3 Abstract Stem cells are a relevant source of information about cellular differentiation molecular processes and tissue homeostasis but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications and taking into account the ethical issue associated with the stem cell therapy. Methods We have searched Pubmed Medline for clinical trials involving the use of human stem cells using the key words stem cells combined with the key words transplantation pathology guidelines properties and risks . All the relevant clinical trials have been included. The results have been divided into different categories basing on the way stem cells have been employed in different pathological conditions. Introduction The word stemness defines a series of properties which distinguish a heterogeneous variety of cell population. However in the absence of a current consensus on a gold standard protocol to isolate and identify SCs the definition of stemness is in a continuous evolution 1-3 . Biologically stem cells SCs are characterized by selfrenewability 4 that is the ability not only to divide themselves rapidly and continuously but also to create new SCs and progenitors more differentiated than the mother cells. The asymmetric mitosis is the process which permits to obtain two intrinsically different daughter cells. A cell polarizes itself so .