tailieunhanh - báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Different patterns of NF- B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma | Su et al. Journal of Experimental Clinical Cancer Research 2011 30 85 http content 30 1 85 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Different patterns of NF-kB and Notchl signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma 1Ỷ 1 Ỷ 1Ỷ 2 3 I z- -4 5 1 Chunhua Su Zhenguang Chen Honghe Luo Yihua Su Wangkai Liu Lie Cai Tao Wang Yiyan Lei and Beilong Zhong6 Abstract Background Lymph node involvement and tumor-induced lymphangiogenesis appear as the earliest features of esophageal squamous cell carcinoma ESCC although the molecular regulatory mechanisms involved have remained unclear. Our aim was to investigate the contribution of NF-kB and Notch1 signaling to lymph node involvement and tumor-induced lymphangiogenesis in ESCC. Material and methods NF-kB and Notch1 expression in 60 tissue samples of ESCC were assessed by immunohistochemical staining. The correlations of NF-kB and Notch1 with lymph node involvement lymphatic vessel density LVD podoplanin and vascular endothelial growth factor-C VEGF-C were further evaluated to determine the association of NF-kB and Notch1 expression with tumor-induced lymphangiogenesis. Results Chi-square tests revealed that NF-kB and Notch1 expression in ESCC tissues were significant associated with lymph node metastasis LVD podoplanin and VEGF-C expression. Strong expression of NF-kB but weak expression of Notch1 was observed in tumor tissues with lymph nodes involvement P for both . The mean histoscores of LVD podoplanin and VEGF-C staining were higher in high-NF-KB-expressing tissue than in low-expressing tissue P for each . In contrast the mean histoscores of LVD and VEGF-C staining were lower in high-Notch1-expressing tissue than in low-expressing tissue P for both . A multiple factors analysis of LVD and VEGF-C further demonstrated that LVD and VEGF-C status were significantly correlated with NF-kB and Notch1 expression in tumors. NF-kB

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