tailieunhanh - báo cáo khoa học: "Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies | Ben Jemaa et al. Journal of Experimental Clinical Cancer Research 2010 29 171 http content 29 1 171 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies A A s o r I -s 1 r r D I I r -s r III 1 c -s 1 -s -s m I 2 KỲ X-. -J o s V ì f r3 l I -s A I Drsn D -s I r 4 I ỉ C-s I IX-. L . 15 Awatef Ben Jemaa Yosra Bouraoui Sataa Sallami Ahmed Banasr Nawfel Ben Rais Laura ouertani Yassin Nouira2 Ali Horchani2 Ridha Oueslati1 Abstract Background The present study was undertaken to relate the co-expression of prostate-associated antigens PSMA and PSA with the degree of vascularization in normal and pathologic hyperplasia and cancer prostate tissues to elucidate their possible role in tumor progression. Methods The study was carried out in 6 normal 44 benign prostatic hyperplastic and 39 cancerous human prostates. Immunohistochemical analysis were performed using the monoclonal antibody CD34 to determine the angiogenic activity and the monoclonal antibodies 3E6 and ER-PR8 to assess PSMA and PSA expression respectively. Results In our study we found that in normal prostate tissue PSMA and PSA were equally expressed and . A significant difference in their expression was see in hyperplastic and neoplastic prostates tissues and respectively for PSMA and and respectively for PSA. Study of prostate tumor profiles showed that the profile PSA PSMA- expression levels decreased between normal prostate benign prostatic tissue and primary prostate cancer. In the other hand the profile PSA- PSMA expression levels increased from normal to prostate tumor tissues. PSMA overexpression was associated with high intratumoral angiogenesis activity. By contrast high PSA expression was associated with low angiogenesis activity. Conclusion These data suggest that these markers are regulated .