tailieunhanh - báo cáo khoa học: " Oncogene addiction in gliomas: Implications for molecular targeted therapy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Oncogene addiction in gliomas: Implications for molecular targeted therapy | Journal of Experimental Clinical Cancer Research Yan et al. Journal of Experimental Clinical Cancer Research 2011 30 58 http content 30 1 58 REVIEW Open Access Oncogene addiction in gliomas Implications for molecular targeted therapy Wei Yant Wei Zhangt and Tao Jiang Abstract Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene and is regarded as the Achilles heel of the successful molecular targeted therapies in cancer. However the role of oncogene addiction in gliomas has not been elucidated systematically. In this review we summarize the current experimental and clinical evidence for the concept of oncogene addiction and describe the mechanisms explaining oncogene addiction in gliomas. And the clinical implications for oncogene addiction in molecular targeted therapy are further emphasized. In addition we discuss future direction for defining complex oncogene addiction network through the integrated analysis of multiple platforms in the flow of genetic information in gliomagenesis. Keywords Oncogene addiction Glioma Molecular targeted therapy Network addiction Introduction Cancer arises as a result of a stepwise accumulation of genetic aberrations 1 . Despite multiple genetic alterations its growth and survival can often be impaired by the inactivation of a single oncogene. This phenomenon indicates that tumors may become dependent upon a single oncogenic activity for both maintenance of the malignant phenotype and cell survival 2 . The phrase oncogene addiction was coined by Bernard Weinstein to describe the observation that tumor maintenance often depends on the continued activity of certain oncogene or loss of tumor suppressor gene 3 . Oncogene addiction provides a rationale for molecular targeted therapy in cancers 4 . More and more researches proposed that decoding of the oncogene addiction in cancer may provide a key for effective cancer therapy. But it