tailieunhanh - Báo cáo y học: "Preliminary investigation of a polyethylene glycol hydrogel "nerve glue""

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Preliminary investigation of a polyethylene glycol hydrogel "nerve glue". | Journal of Brachial Plexus and Peripheral Nerve Injury BioMed Central Research article Open Access Preliminary investigation of a polyethylene glycol hydrogel nerve glue Jonathan Isaacs 1 Ivette Klumb2 and Candice McDaniel1 Address Department of Orthopaedic Surgery Virginia Commonwealth University Health System Richmond Virginia USA and 2Division of Plastic and Reconstructive Surgery Department of General Surgery Virginia Commonwealth University Health System Richmond Virginia USA Email Jonathan Isaacs - jisaacs@ Ivette Klumb - iklumb@ Candice McDaniel - Corresponding author Published 15 September 2009 Received 27 May 2009 Journal of Brachial Plexus and Peripheral Nerve Injury 2009 4 16 doi l 749-7221-4-16 Accepted 15 September 2009 This article is available from http content 4 1 16 2009 Isaacs et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Polyethylene glycol PEG hydrogel is a biocompatible semi-adherent gel like substance that can potentially augment nerve repair much like a fibrin sealant. Potential advantages of this substance include fast preparation and set up time as well as adhesion inhibiting properties. The purpose of this study was to perform an initial evaluation of PEG hydrogel in this application. Methods The sciatic nerves of 29 rats were transected and repaired using two 10-0 nylon sutures and either PEG hydrogel or fibrin glue. After l0 weeks contraction forces of the reinnervated muscles were evaluated and histological assessment of scar tissue performed. Results Muscle strength testing revealed the average ratio of experimental to control sides for the fibrin glue group was and for the PEG hydrogel .