tailieunhanh - báo cáo khoa học: "The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients | Xishan et al. Journal of Experimental Clinical Cancer Research 2011 30 47 http content 30 1 47 Journal of Experimental Clinical Cancer Research RESEARCH Open Access The research on the immuno-modulatory defect of Mesenchymal Stem Cell from Chronic Myeloid Leukemia patients Zhu Xishan An Guangyu Song Yuguang and Zhang Hongmei Abstract Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not found in the majority of the leukemic cells. These leukemic stem cells are necessary and sufficient to maintain the leukemia. While the hematopoietic stem cell HSC origin of CML was first suggested over 30 years ago recently CML-initiating cells beyond HSCs are also being investigated. We have previously isolated fetal liver kinase-1-positive Flk1 cells carrying the BCR ABL fusion gene from the bone marrow of Philadelphia chromosome-positive Ph patients with hemangioblast property. Here we showed that CML patient-derived Flk1 CD31-CD34-MSCs had normal morphology phenotype and karyotype but appeared impaired in immuno-modulatory function. The capacity of patient Flk1 CD31-CD34- MSCs to inhibit T lymphocyte activation and proliferation was impaired in vitro. CML patient-derived MSCs have impaired immuno-modulatory functions suggesting that the dysregulation of hematopoiesis and immune response may originate from MSCs rather than HSCs. MSCs might be a potential target for developing efficacious cures for CML. Introduction Chronic Myeloid Leukemia CML is a malignant myeloproliferative disorder originating from a pluripotent stem cell that expresses the BCR ABL oncogene and is characterized by abnormal release of the expanded malignant stem cell clone from the bone marrow into the circulation 1 2 . The discovery of the .

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