tailieunhanh - báo cáo hóa học:" Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model | Journal of Orthopaedic Surgery and Research BioMed Central Research article Thrombin related peptide TP508 promoted fracture repair in a mouse high energy fracture model Brain M Hanratty1 James T Ryaby2 Xiao-Hua Pan3 and Gang Li 1 4 Address Department of Orthopaedic Surgery School of Biomedical Sciences Queen s University Belfast 97 Lisburn Road Belfast BT9 7B UK 2Research and Development OrthoLogic Corp 1275 West Washington Street Tempe AZ USA 3Department of Orthopaedic Surgery People s Hospital of Shenzhen City Shenzhen PR China and 4Department of Orthopaedics Traumatology The Chinese University Hong Kong Clinical Sciences Building Prince of Wales Hospital Shatin Hong Kong PR China Email Brain M Hanratty - bmhanratty@ James T Ryaby - jamesryaby@ Xiao-Hua Pan - szpxh4141@ Gang Li - Corresponding author Open Access Published 29 January 2009 Received 12 August 2008 Journal of Orthopaedic Surgery and Research 2009 4 1 doi l749-799X-4-l Accepted 29 January 2009 This article is available from http content 4 l l 2009 Hanratty et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Thrombin related peptide TP508 is a 23 amino-acid synthetic peptide that represents a portion of the receptor-binding domain of thrombin molecule. Previous studies have shown that TP508 can accelerate musculoskeletal tissue repair including fracture healing. Objectives The aim of this study was to investigate the effect of TP508 on fracture healing in a murine fracture model representing high energy fracture situation. Methods Eighty CD l mice underwent controlled quadriceps muscle .