tailieunhanh - báo cáo khoa học: " AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma: are different ultrasound patterns related to different variants? | Solivetti et al. Journal of Experimental Clinical Cancer Research 2011 30 40 http content 30 1 40 Journal of Experimental Clinical Cancer Research RESEARCH Open Access AIDS-Kaposi Sarcoma and Classic Kaposi Sarcoma are different ultrasound patterns related to different variants l l Cialix dtri 1 ik ia pli .i A loccaaalra I tini2 r- .irla it . 3 Aoirdiali-l-di4 a a al A lala mi aria 5 Francesco M Soiivetti ruivia Ella Alessandra Latin Carlo Cota raoia Cordiaii rei and Aldo Di Carlo Abstract Background Kaposi Sarcoma KS is a malignancy of endothelial skin cells with multifocal localization on the skin lymph nodes and visceral organs. Although all clinical variants are associated with HHV-8 infection specific differences in the clinical onset and in the natural history of AIDS-KS and Classic-KS have been described. The present randomised prospective-observational study aimed to investigate whether the ultrasound pattern and color Doppler flow imaging of vascularisation of skin lesions of patients with Classic KS CKS or AIDS-KS could provide useful information to the evaluation of clinical activity of the disease. Methods Cutaneous lesions of 24 patients with histologically confirmed KS were investigated using very high frequency ultrasound probes 16 patients had CKS and 8 had AIDS-KS. HHV-8 infection was confirmed in all patients by investigating the specific humoral response to viral antigens. Immunological and virological parameters were also assessed to monitor HIV or HHV-8 viral infection. ror each patient a target skin lesion was selected on the basis of size diameter from to 2 cm . Each lesion was analyzed in terms of size depth and color Doppler pattern. Results The B-mode ultrasound patterns of skin lesions did not differ when comparing CKS patients to AIDS-KS patients whereas the color Doppler signal which is associated with vascular activity was detected in the KS lesions of 6 8 AIDS-KS patients and in 2 16 CKS 16 7 the .