tailieunhanh - báo cáo khoa học: "Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation | Koh et al. Journal of Experimental Clinical Cancer Research 2011 30 36 http content 30 1 36 Journal of Experimental Clinical Cancer Research RESEARCH Open Access Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation 1 1 1 1 1 1 Hideo Koh Hirohisa Nakamae Kiyoyuki Hagihara Takahiko Nakane Masahiro Manabe Yoshiki Hayashi 1 1 111 1 Mitsutaka Nishimoto Yukari Umemoto Mika Nakamae Asao Hirose Eri Inoue Atsushi Inoue 11 1111 Masahiro Yoshida Masato Bingo Hiroshi Okamura Ran Aimoto Mizuki Aimoto Yoshiki Terada Ki-Ryang Koh 1 Takahisa Yamane1 Masahiko Ohsawa2 and Masayuki Hino1 Abstract Background There has been insufficient examination of the factors affecting long-term survival of more than 5 years in patients with leukemia that is not in remission at transplantation. Method We retrospectively analyzed leukemia not in remission at allogeneic hematopoietic cell transplantation allo-HCT performed at our institution between January 1999 and July 2009. Forty-two patients with a median age of 39 years received intensified conditioning n 9 standard n 12 or reduced-intensity conditioning n 21 for allo-HCT. Fourteen patients received individual chemotherapy for cytoreduction during the three weeks prior to reduced-intensity conditioning. Diagnoses comprised acute leukemia n 29 chronic myeloid leukemia-accelerated phase n 2 myelodysplastic syndrome acute myeloid leukemia MDS AML n 10 and plasma cell leukemia n 1 . In those with acute leukemia cytogenetic abnormalities were intermediate 44 or poor 56 . The median number of blast cells in bone marrow BM was range before the start of chemotherapy for allo-HCT. Six patients had leukemic involvement of the central nervous system. Stem cell sources were related BM 7 related peripheral blood 31 unrelated BM 48 and unrelated cord blood CB 14 . Results Engraftment was achieved in 33 79 of 42 patients. Median time to engraftment .