tailieunhanh - báo cáo khoa học: "EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features | Li et al. Journal of Experimental Clinical Cancer Research 2011 30 27 http content 30 1 27 RESEARCH Journal of Experimental Clinical Cancer Research Open Access EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features 1 1 2 2 1 I- 1 t 1 t Feng Li Yongmei Liu Huijiao Chen Dianying Liao Yali Shen Feng Xu Jin Wang 1 Abstract Background To evaluate the expression of EGFR and COX-2 and their correlation with prognosis in NSCLC Methods The paraffin embedded tumor samples of 50 NSCLC patients receiving radical resection were analyzed immunohistochemically for EGFR and COX-2 expression and their prognostic values were explored. Results The positive rate of EGFR protein in NSCLC tumor cells was 46 which was significantly higher than its expression in normal lung p and paracancerous tissues p . EGFR expression was significantly higher in nodal positive than in nodal negative patients p . The mean survival time for EGFR positive patients 31 months was significantly lower than that for patients with EGFR negative expression 48 months p . In patients receiving post-operation thoracic irradiation the mean survival time for EGFR positive patients was significantly lower than that for patients without EGFR positive expression 25 vs. 48 months P . The positive rate of COX-2 protein expression in NSCLC tumor cells was 90 which was significantly higher than that in normal tissue p and paracancerous tissue p . There was no correlation between COX-2 expression and patient survival and no correlation between COX-2 and EGFR protein expression P . Conclusions COX-2 and EGFR are over-expressed in NSCLC. EGFR is an independent prognostic factor and a predictive factor for radiotherapy response in NSCLC. Background Lung cancer is the leading cause of death world wide. The non-small cell lung cancer NSCLC accounts for 75-85 among all lung cancers. The conventional treatment . .