tailieunhanh - báo cáo hóa học:" High abundances of neurotrophin 3 in atopic dermatitis mast cell"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : High abundances of neurotrophin 3 in atopic dermatitis mast cell | Journal of Occupational Medicine and Toxicology BioMed Central Research High abundances of neurotrophin 3 in atopic dermatitis mast cell David Quarcoo 1 Tanja C Fischer2 Nora Peckenschneider3 David A Groneberg1 and Pia Welker3 Open Access Address 1Institute of Occupational Medicine Charité - Universitatsmedizin Berlin Free University and Humboldt University D-14195 Berlin Germany 2Department of Dermatology and Allergy Charité - Universitatsmedizin Berlin Free University and Humboldt University D-10115 Berlin Germany and institute of Anatomy Charité - Universitatsmedizin Berlin Free University and Humboldt University D-10115 Berlin Germany Email David Quarcoo - Tanja C Fischer - Nora Peckenschneider - David A Groneberg - Pia Welker - Corresponding author Published 22 April 2009 Received 16 October 2008 Journal of Occupational Medicine and Toxicology 2009 4 8 doi 1745-6673-4-8 Accepted 22 April 2009 This article is available from http content 4 1 8 2009 Quarcoo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Neurotrophin 3 NT-3 is a member of the neurotrophin family a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases. Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far. Objective Characterize NT-3 on a transcriptional and translational level in individuals with atopic dermatitis with special focus on mast cells. Methods To meet this objective NT-3 levels in the serum of AD patients were measured the effect of