tailieunhanh - báo cáo hóa học:" Effects of rock wool on the lungs evaluated by magnetometry and biopersistence test"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Effects of rock wool on the lungs evaluated by magnetometry and biopersistence test | Journal of Occupational Medicine and Toxicology BioMed Central Research Effects of rock wool on the lungs evaluated by magnetometry and biopersistence test Yuichiro Kudo 1 Makoto Kotani1 Masayuki Tomita2 and Yoshiharu Aizawa1 Open Access Address Department of Preventive Medicine and Public Health Kitasato University School of Medicine 1-15-1 Kitasato Sagamihara Kanagawa 228-8555 Japan and 2NICHIAS Corporation 1-26 Shibadaimon 1-chome Minato-ku Tokyo 105-8555 Japan Email Yuichiro Kudo - yuichiro@ Makoto Kotani - mkotani@ Masayuki Tomita - tomita-m@ Yoshiharu Aizawa - aizawa@ Corresponding author Published 27 March 2009 Received 30 October 2008 rr. . . . _ À r Accepted 27 March 2009 Journal of Occupational Medicine and Toxicology 2009 4 5 doi 86 1745-6673-4-5 This article is available from http content 4 1 5 2009 Kudo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Asbestos has been reported to cause pulmonary fibrosis and its use has been banned all over the world. The related industries are facing an urgent need to develop a safer fibrous substance. Rock wool RW a kind of asbestos substitute is widely used in the construction industry. In order to evaluate the safety of RW we performed a nose-only inhalation exposure study in rats. After one-month observation period the potential of RW fibers to cause pulmonary toxicity was evaluated based on lung magnetometry findings pulmonary biopersistence and pneumopathology. Methods Using the nose-only inhalation exposure system 6 male Fischer 344 rats 6 to 10 weeks old were exposed to RW fibers at a target fiber concentration of 100 fibers cm3 length L 20 pm for 6 .