tailieunhanh - Báo cáo y học: "Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia? | Sahin et al. Journal of Cardiothoracic Surgery 2011 6 31 http content 6 1 31 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia 1 2 1 1 1 1 3 Mehmet A Sahin Orhan Yucel Adem Guler Suat Doganci Artan Jahollari Faruk Cingoz Siddik Arslan Mehmet Gamsizkan4 Halil Yaman5 Ufuk Demirkilic1 Abstract Background The aim of the present study was to investigate the cardioprotective effect of Taurine on the donor hearts during cold ischemic period. Methods 32 rats were divided into four groups sham taurine ischemia treatment group 8 rats in each . All rats were fed with rat food for three weeks. Taurine and treatment groups were given a 200 mg kg day dose of Taurine by oral gavage besides rat feed. Cardiectomy was performed in all rats after three weeks. In ischemia and treatment groups harvested hearts were kept in sodium chloride at 4 degrees C for 5 hours. Tissue samples were taken from left ventricle in all groups. These samples were evaluated by histopathologic and biochemical examination. Results In the present study results of the biochemical and histopathological examination reveals the protective effects of Taurine. As a marker of lipid peroxidation Malondialdehyde MDA levels in ischemia group were significantly higher than both Sham and Taurine groups. MDA values were recorded in the sham group in the Taurine group in the ischemia group and in the treatment group. MDA levels decreased in treatment group. p In accordance with MDA findings while superoxide dismutase and glutathione peroxidase levels decreased in ischemia group they increased in treatment group. p There was no differences in Catalase CAT enzyme level between treatment and ischemia group p . CAT level results were recorded in the sham group in the Taurine group

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
TÀI LIỆU MỚI ĐĂNG
6    88    0    29-04-2024
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.