tailieunhanh - Báo cáo y học: " Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind . | Papadopoulos et al. Journal of Cardiothoracic Surgery 2010 5 17 http content 5 1 17 JOTS JOURNAL OF CARDIOTHORACIC SURGERY STUDY PROTOCOL Open Access Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind randomized study rz i I z 1 D k s I z k . z I 11 z 1 1 t c I I Cl Fz I I 1 t c z r r c I m I I s 1 1 r 21 r I z 1 IX z I - - r i r 3 t l I I l z I z r D s 11 z I I 1 1 I r 3 t Georgios Papadopoulos Eleni sintou Stavros siminelakis Efstratios Koletsis iNiKoiaos G Baikoussis Efstratios Apostolakis3t Abstract Preoperative medication by inhibitors of angiotensin-converting enzyme ACE in coronary artery patients predisposes to vasoplegic shock early after coronary artery bypass grafting. Although in the majority of the cases this shock is mild in some of them it appears as a situation intractable to high-catecholamine dose medication. In this study we examined the possible role of prophylactic infusion of low-dose vasopressin during and for the four hours post-bypass after cardiopulmonary bypass in an effort to prevent this syndrome. In addition we studied the influence of infused vasopressin on the hemodynamics of the patients as well as on the postoperative urine-output and blood-loss. In our study 50 patients undergoing coronary artery bypass grafting were included in a blind-randomized basis. Two main criteria were used for the eligibility of patients for coronary artery bypass grafting ejection fraction between 30-40 and patients receiving ACE inhibitors at least for four weeks preoperatively. The patients were randomly divided in two groups the group A who were infused with IU min vasopressin and the group B who were infused with normal saline intraoperativelly and for the 4 postoperative hours. Measurements of mean artery pressure MAP central venous pressure CVP systemic vascular resistance SVR .