tailieunhanh - báo cáo hóa học:" Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development Hui Sheng1 2 Ge Zhang1 Wing Hoi Cheung1 Chun Wai Chan1 Yi Xiang Wang4 Kwong Man Lee3 Hong Fu Wang2 Kwok Sui Leung1 and Ling Qin 1 Address Department of Orthopaedics Traumatology The Chinese University of Hong Kong Hong Kong China 2Department of Bone Metabolism The Institute of Radiation Medicine Fudan University Shanghai China 3Lee Hysan Clinical Research Laboratory The Chinese University of Hong Kong Hong Kong China and 4Department of Diagnostic Radiology Organ Imaging The Chinese University of Hong Kong Hongkong China Email Hui H Sheng - shenghui@ Ge G Zhang - zhangge@ Wing Hoi WH Cheung - louis@ Chun Wai CW Chan - chanwai@ Yi Xiang YX Wang - yixiang_wang@ Kwong Man KM Lee - simonlee@ Hong Fu HF Wang - hfwang@ Kwok Sui KS Leung - ksleung@ Ling L Qin - lingqin@ Corresponding author Published 15 October 2007 Received 18 December 2006 Journal of Orthopaedic Surgery and Research 2007 2 15 doi 86 I749-799X-2-15 Accepted 15 October 2007 This article is available from http content 2 1 15 2007 Sheng et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Increased bone marrow lipid deposition in steroid-associated osteonecrosis ON implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be explained by elevated adipogenesis of marrow mesenchymal stem cells MSCs . However it remains unclear whether there .