tailieunhanh - Báo cáo y học: "hree-dimension structure of ventricular myocardial fibers after myocardial infarctio"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Three-dimension structure of ventricular myocardial fibers after myocardial infarction. | Gao et al. Journal of Cardiothoracic Surgery 2010 5 116 http content 5 1 116 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Three-dimension structure of ventricular myocardial fibers after myocardial infarction Changqing Gao Weihua Ye Libin Li Abstract Background To explore the pathological changes of three-dimension structure of ventricular myocardial fibers after anterior myocardial infarction in dog heart. Methods Fourteen acute anterior myocardial infarction models were made from healthy dogs mean weight kg . Six out of 14 dogs with old myocardial infarction were sacrificed and their hearts were harvested after they survived the acute anterior myocardial infarction for 3 months. Each heart was dissected into ventricular myocardial band VMB morphological characters in infarction region were observed and infarct size percents in descending segment and ascending segment were calculated. Results Six dog hearts were successfully dissected into VMB. Uncorresponding damages in myocardial fibers of descending segment and ascending segment were found in apical circle in anterior wall infarction. Infarct size percent in the ascending segment was significantly larger than that in the descending segment SD vs P the long axis of infarction area was perpendicular to the orientation of myocardial fibers in ascending segment however the long axis of the infarction area was parallel with the orientation of myocardial fibers in descending segment. Conclusions We found that damages were different in both morphology and size in ascending segment and descending segment in heart with myocardial infarction. This may provide an important insight for us to understand the mechanism of heart failure following coronary artery diseases. Background Postinfarct ventricular remodeling PIVR is the major cause of heart failure following coronary artery disease 1 . Microcosmically PIVR has been recognized on