tailieunhanh - Báo cáo y học: "Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries. | Ranieri et al. Journal of Brachial Plexus and Peripheral Nerve Injury 2010 5 15 http content 5 1 15 JOURNAL OF BRACHIAL PLEXUS AND PERIPHERAL NERVE INJURY LETTER TO THE EDITOR Open Access Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries 1 1 1 1 2 1 Maurizio Ranieri Manuela Sciuscio Annamaria Cortese Marilena Stasi Francesco Panza Marisa Megna Pietro Fiore3 Andrea Santamato3 Abstract Recent findings on the antioxidant effects of pretreatment with a-lipoic acid a-LA on the crush injury of rat sciatic nerve confirm the possible usefulness of a-LA administration in humans with peripheral nerve injuries. We discussed this issue in relation with our recent results in which the combined employment of a-LA and g-linolenic acid with a rehabilitation program for six weeks reduced sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict in comparison with patients submitted to rehabilitation program alone for six weeks. Dear Editors We read with great interest the paper Intraperitoneal alpha-lipoic acid to prevent neural damage after crush injury to the rat sciatic nerve by Senoglu and colleagues published in the November issue 2009 of the Journal of Brachial Plexus and Peripheral Nerve Injury 1 . We congratulate the Journal for the interest in this topic. This innovative study demonstrated the protective effect of a -lipoic acid a-LA administration in rat sciatic nerve crush injury by reducing the oxidative stress 1 . This paper has aroused our attention because these findings can provide confirmation on the usefulness of a-LA administration in humans in a very common disease as back pain 2 which produces adverse effects on activities of daily living. Back pain is a common and disabling musculoskeletal disorder that often occurs in a working-age population. Sciatic nerve injury is a common consequence of low back pain caused by lumbar disc herniation that occurs with