tailieunhanh - Báo cáo y học: "Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report. | Ogawa et al. Journal of Cardiothoracic Surgery 2010 5 115 http content 5 1 115 JOTS JOURNAL OF CARDIOTHORACIC SURGERY CASE REPORT Open Access Thymic large cell neuroendocrine carcinoma report of a resected case - a case report 11 112 2 1 Fumihiro Ogawa Akira lyoda Hideki Amano Kenji Nezu Shi-Xu Jiang Isao Okayasu Yukitoshi Satoh Abstract Thymic large cell neuroendocrine carcinomas LCNECs are very rare. We here describe a case in which the tumor could be completely resected. A 55-year-old male was admitted to our hospital for treatment of an anterior mediastinal tumor found at a regular health check-up. The patient underwent an extended thymectomy of an invasive thymoma of Masaoka s stage II that had been suspected preoperatively. The tumor was located in the right lobe of the thymus and was completely resected. Final pathological diagnosis of the surgical specimen was thymic LCNEC. The patient underwent adjuvant chemotherapy with irinotecan and cisplatin in accordance with the diagnosis of a lung LCNEC and is alive without recurrence or metastasis 16 months after surgery. Background Primary thymic neuroendocrine carcinomas NECs were categorized under the rubric of thymomas until 1972 when Rosai and Higa suggested that these tumors were sufficiently distinctive to warrant classification as carcinoid tumors 1 . Thymic NECs are relatively rare neoplasms that account for only approximately 2 to 4 of all anterior mediastinal neoplasms 2 . In 1999 the World Health Organization established thymic epithelial tumor criteria and reclassified thymic carcinoma referring to NECs as a subtype 3 . In particular the LCNEC was subclassified in the thymic NECs in accordance with the classification of pulmonary neuroendocrine tumors. Detailed clinical features of thymic LCNECs are still unknown however because of their rareness. We described a case with a review of the literature focusing on the most likely optimal treatment it. Case presentation A .