tailieunhanh - Báo cáo y học: "Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass. | Tirilomis et al. Journal of Cardiothoracic Surgery 2010 5 98 http content 5 1 98 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Myocardial contractile function in survived neonatal piglets after cardiopulmonary bypass Theodor Tirilomis Oliver J Liakopoulos K Oguz Coskun Marc Bensch Aron-Frederik Popov Jan D Schmitto Friedrich A Schoendube Abstract Background Hemodynamic function may be depressed in the early postoperative stages after cardiac surgery. The aim of this study was the analysis of the myocardial contractility in neonates after cardiopulmonary bypass CPB and mild hypothermia. Methods Three indices of left ventricular myocardial contractile function dP dt dP dt P and wall thickening were studied up to 6 hours after CPB in neonatal piglets CPB group n 4 . The contractility data were analysed and then compared to the data of newborn piglets who also underwent median thoracotomy and instrumentation for the same time intervals but without CPB non-CPB group n 3 . Results Left ventricular dP dtmax and dP dtmax P remained stable in CPB group while dP dtmax decreased in non-CPB group 5 hours postoperatively 1761 205 mmHg s at baseline vs. 1170 205 mmHg s after 5 h p . However with regard to dP dtmax and dP dtmax P there were no statistically significant differences between the two groups. Comparably although myocardial thickening decreased in the non-CPB group the differences between the two groups were not statistically significant. Conclusions The myocardial contractile function in survived neonatal piglets remained stable 6 hours after cardiopulmonary bypass and mild hypothermia probably due to regional hypercontractility. Introduction The postoperative course after cardiac surgery in infants and children is in most cases uneventful. However in some cases hemodynamic deterioration was observed early after surgery. The first characteristic change is regarding systemic blood pressure. The cause may be .