tailieunhanh - Báo cáo y học: "Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds. | Torbrand et al. Journal of Cardiothoracic Surgery 2010 5 75 http content 5 1 75 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Wound contraction and macro-deformation during negative pressure therapy of sternotomy wounds 1 2 2 2 3 1 Christian Torbrand Martin Ugander Henrik Engblom Hakan Arheden Richard Ingemansson Malin Malmsjo Abstract Background Negative pressure wound therapy NPWT is believed to initiate granulation tissue formation via macro-deformation of the wound edge. However only few studies have been performed to evaluate this hypothesis. The present study was performed to investigate the effects of NPWT on wound contraction and wound edge tissue deformation. Methods Six pigs underwent median sternotomy followed by magnetic resonance imaging in the transverse plane through the thorax and sternotomy wound during NPWT at 0 -75 -125 and -175 mmHg. The lateral width of the wound and anterior-posterior thickness of the wound edge was measured in the images. Results The sternotomy wound decreased in size following NPWT. The lateral width of the wound at the level of the sternum bone decreased from 39 7 mm to 30 6 mm at -125 mmHg p . The greatest decrease in wound width occurred when switching from 0 to -75 mmHg. The level of negative pressure did not affect wound contraction sternum bone 32 6 mm at -75 mmHg and 29 6 mm at -175 mmHg p . The decrease in lateral wound width during NPWT was greater in subcutaneous tissue 14 2 mm than in sternum bone 9 2 mm resulting in a ratio of p suggesting macro-deformation of the tissue. The anterior-posterior thicknesses of the soft tissue at and cm laterally from the wound edge were not affected by negative pressure. Conclusions NPWT contracts the wound and causes macro-deformation of the wound edge tissue. This shearing force in the tissue and at the wound-foam interface may be one of the mechanisms by which negative pressure delivery .