tailieunhanh - Báo cáo y học: "Autonomic cardiovascular dysregulation as a potential mechanism underlying depression and coronary artery bypass grafting surgery outcomes."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Autonomic cardiovascular dysregulation as a potential mechanism underlying depression and coronary artery bypass grafting surgery outcomes. | Dao et al. Journal of Cardiothoracic Surgery 2010 5 36 http content 5 1 36 JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Auto nomic cardiovascular dysregulation as a potential mechanism underlying depression and coronary artery bypass grafting surgery outcomes Tam K Dao 41 3 8 Nagy A Youssef35 6 7 8 Raja R Gopaldas44 8 Danny Chu2 4 8 Faisal Bakaeen2 4 8 Emily Wear41 8 and Deleene Menefee2 4 8 Abstract Background Coronary artery bypass grafting CABG is often used to treat patients with significant coronary heart disease CHD . To date multiple longitudinal and cross-sectional studies have examined the association between depression and CABG outcomes. Although this relationship is well established the mechanism underlying this relationship remains unclear. The purpose of this study was twofold. First we compared three markers of autonomic nervous system ANS function in four groups of patients 1 Patients with coronary heart disease and depression CHD Dep 2 Patients without CHD but with depression NonCHD Dep 3 Patients with CHD but without depression CHD NonDep and 4 Patients without CHD and depression NonCHD NonDep . Second we investigated the impact of depression and autonomic nervous system activity on CABG outcomes. Methods Patients were screened to determine whether they met some of the study s inclusion or exclusion criteria. ANS function . heart rate heart rate variability and plasma norepinephrine levels were measured. Chi-square and one-way analysis of variance were performed to evaluate group differences across demographic medical variables and indicators of ANS function. Logistic regression and multiple regression analyses were used to assess impact of depression and autonomic nervous system activity on CABG outcomes. Results The results of the study provide some support to suggest that depressed patients with CHD have greater ANS dysregulation compared to those with only CHD or depression. Furthermore .