tailieunhanh - Báo cáo y học: " Effects of ischemic preconditioning on ischemia/ reperfusion-induced arrhythmias by upregulatation of connexin 43 expression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of ischemic preconditioning on ischemia/ reperfusion-induced arrhythmias by upregulatation of connexin 43 expression. | Chen et al. Journal of Cardiothoracic Surgery 2011 6 80 http content 6 1 80 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Effects of ischemic preconditioning on ischemia reperfusion-induced arrhythmias by upregulatation of connexin 43 expression 1 1 2 I z- 3 1 1 1 Zhenguang Chen Honghe Luo Mei Zhuang Lie Cai Chunhua Su Yiyan Lei and Jianyong Zou Abstract Background The susceptibility of hypertrophied myocardium to ischemia-reperfusion injury is associated with increased risk of postoperative arrhythmias. We investigate the effects of ischemic preconditioning IP on post-ischemic reperfusion arrhythmias in hypertrophic rabbit hearts. Methods Thirty-three rabbit models of myocardial hypertrophy were randomly divided into three groups of 11 each non-ischemia-reperfusion group group A ischemia-reperfusion group group B and ischemic preconditioning group group C . Another ten healthy rabbits with normal myocardium served as the healthy control group. Rabbit models of myocardial hypertrophy were induced by abdominal aortic banding. Surface electrocardiogram ECG was recorded and Curtis-Ravingerova score was used for arrhythmia quantification. Connexin 43 Cx43 expression was assessed by immunohistochemistry. Results Ratios of heart weight to body weight and left ventricular weight to body weight increase significantly in the three groups compared with the healthy control group p . Arrhythmia incidence in group C is significantly lower than group B p . Curtis-Ravingerova score in group C is lower than group B p . Cx43 expression area in group A is smaller by comparison with the healthy control group p . Cx43 expression area and fluorescence intensity in group B are reduced by and respectively compared with group A p . In group C Cx43 expression area increases by compared with group B p and decreases by compared with group A p . Conclusions The incidence of ischemia .

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