tailieunhanh - Báo cáo y học: "Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting. | Visser et al. Journal of Cardiothoracic Surgery 2011 6 36 http content 6 1 36 JCTS JOURNAL OF CARDIOTHORACIC SURGERY STUDY PROTOCOL Open Access Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative par enteral nutrition on amino acid profile cardiomyocytes structure and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting l lliolzo iccar1 2 rÌTỉx iHc3 I Iciifi I Vorhama4 ỉ ỉf ifor EK I kWl 5 A K I Mioccon6 7 I Cififix l l A onrr ir tii1 Mailieke vissei Maiiska Davids Heii J veibeiie Woutei EM Kok Hais WM Niessei Leiiiiy MW vai veiiooij Riccardo Cocchieii1 Willem Wisseliik2 7 Bds AJM de Mol1 and Paul AM van Leeuwen2 7 Abstract Background Malnutrition is veiy commoi ii patieits uide caidiac suigeiy. Malnutrition cai chaige myocaidial substrate utilizatioi which cai iiduce adveise effects oi myocaidial metabolism aid fuictioi. We aim to iivestigate the hypothesis that theie is a distuibed amiio acids profile ii the caidiac suigical patieit which cai be ioimalized by pai eiteial iutiitioi befoie duiiig aid aftei suigeiy subsequeitly impioviig caidiomyocyte stiuctuie caidiac peifusioi aid glucose metabolism. Methods Design This randomized coitiolled iiteiveitioi study iivestigates the effect of uiiiteiiupted peiiopeiative pai eiteial iutiitioi oi caidiac fuictioi ii 48 patieits uideigoiig coioiaiy aiteiy bypass giaftiig. Patieits aie givei eiteial iutiitioi i 16 oi paieiteial iutiitioi i 16 at least two days befoie duiiig aid two days aftei coioiaiy aiteiy bypass giaftiig oi aie tieated accoidiig to the staidaid guideliies coitiol i 16 . We will illustrate the effect of pai eiteial iutiitioi oi diffeieices ii coiceitiatiois of amiio acids aid asymmetiic dimethylaigiiiie aid ii activity of dimethylaigiiiie dimethylamiiohydiolase aid aigiiase ii caidiac tissue aid blood plasma. li additioi caidiomyocyte stiuctuie by histological immuio-histochemical aid .