tailieunhanh - Báo cáo y học: " Lung sealant and morbidity after pleural decortication: a prospective randomized, blinded study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Lung sealant and morbidity after pleural decortication: a prospective randomized, blinded study. | Bertolaccini et al. Journal of Cardiothoracic Surgery 2010 5 45 http content 5 1 45 JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Lung sealant and morbidity after pleural decortication a prospective randomized blinded study Luca Bertolaccini 1 Paraskevas Lybéris2 and Emilpaolo Manno3 Abstract Objectives Prolonged postoperative air leaks AL are a major cause of morbidity. Aim of this work was evaluating use of a Lung Sealant System Pleuraseal Covidien Mansfield MA . in pleural decortications for empyema thoracis. Methods From January 2008 to December 2008 46 consecutive patients received pleural decortications for empyema thoracis. Post-procedural and malignancy-related empyemas were excluded. After hydro-pneumatic test and surgical correction of AL until satisfaction patients were assigned 23 per group to Control or Sealant group. Control group underwent no additional interventions. In Sealant group lung sealant was applied over AL areas. Following variables were measured daily patients with AL time to chest drainage CD removal CD drainage volume at removal postoperative length of hospital stay postoperative C-reactive protein CRP and leukocyte counts. Personnel recording parameters were blinded to intervention. Two-tailed t-tests normally distributed data or Mann - Whitney U-test not-normally distributed data were used for evaluating significance of differences between group means or medians. Significance of any proportional differences in attributes were evaluated using Fisher s Exact Test. Statistical analysis was carried out using R-software version . Results Groups were similar regarding demographic and baseline characteristics. No patients were withdrawn from study no adverse effects were recorded. There were no significative differences on CRP and leukocyte levels between two groups. Compared with the Control group in Sealant group significantly fewer patients had AL 30 versus 78 p and drains .