tailieunhanh - GLIOMA – EXPLORING ITS BIOLOGY AND PRACTICAL RELEVANCE

The cellular damage due to the hypoxi/re-oxigenative stress may trigger the production of free radicals with consequent destabilization of the cell membranes (Calandrella et al., 2010). As a matter of fact literature data show that the ischemic insult at retinal level activates iNOS which leads to the production of nitrogen oxide (Goldstein et al., 1995; Geyer et al., 1995): this compound is cytotoxic at high concentration and causes lipid peroxidation (Crow et al., 1996; Ullrich et al., 2000). It was also shown that iNOS expression is responsible for the retinal cell death both in vitro and in vivo. | GLIOMA - EXPLORING ITS BIOLOGY AND PRACTICAL RELEVANCE Edited by Anirban Ghosh Glioma - Exploring Its Biology and Practical Relevance Edited by Anirban Ghosh Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which permits to copy distribute transmit and adapt the work in any medium so long as the original work is properly cited. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer Jan Hyrat Image Copyright Jason Adamson 2011. First published September 2011 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Glioma - Exploring Its Biology and Practical Relevance Edited by Anirban Ghosh p. cm. ISBN 978-953-307-379-8 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER INTECH open free online editions of InTech Books and Journals can be found at

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