tailieunhanh - báo cáo hóa học: " Screening for tuberculosis and prediction of disease in Portuguese healthcare workers"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Screening for tuberculosis and prediction of disease in Portuguese healthcare workers | Torres Costa et al. Journal of Occupational Medicine and Toxicology 2011 6 19 http content 6 1 19 _ JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Screening for tuberculosis and prediction of disease in Portuguese healthcare workers José Torres Costa1 2 Rui Silva1 2 Felix C Ringshausen 3 and Albert Nienhaus3 Abstract Introduction Results of systematic screening of healthcare workers HCWs for tuberculosis TB with the tuberculin skin test TST and interferon-g release assays IGRA in a Portuguese hospital from 2007 to 2010 are reported. Methods All HCWs are offered screening for TB. Screening is repeated depending on risk assessment. TST and QuantiFERON Gold In-Tube QFT are used simultaneously. X-ray is performed when TST is 10 mm IGRA is positive or typical symptoms exist. Results The cohort comprises 2 889 HCWs. TST and IGRA were positive in TST-positive but IGRA-negative results were apparent in . Active TB was diagnosed in twelve HCWs - eight cases were detected during screening and four cases were predicted by IGRA as well as by TST. However the progression rate in IGRA-positive was higher than in TST-positive HCWs vs. p-value . Conclusions The TB burden in this cohort was high per 100 000 HCWs . However the progression to active TB after a positive TST or positive IGRA was considerably lower than that reported in literature for close contacts in low-incidence countries. This may indicate that old LTBI prevails in these HCWs. Introduction Screening healthcare workers HCWs for latent tuberculosis infection LTBI and active tuberculosis TB disease is fundamental in infection control programmes in hospitals 1 . The tuberculin skin test TST was the first method available for detecting LTBI. However the TST has known limitations including cross-reactivity with bacillus Calmette-Guérin BCG and non-tubercu-lous mycobacteria NTM infections 2 . Recently new in vitro assays that measure interferon IFN -g .