tailieunhanh - Báo cáo y học: " Bioinformatic-driven search for metabolic biomarkers in disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Bioinformatic-driven search for metabolic biomarkers in disease. | Baumgartner et al. Journal of Clinical Bioinformatics 2011 1 2 http content 1 1 2 JOURNAL OF CLINICAL BIOINFORMATICS REVIEW Open Access Bioinformatic-driven search for metabolic biomarkers in disease 1 1 1 2 Christian Baumgartner Melanie Osl Michael Netzer Daniela Baumgartner Abstract The search and validation of novel disease biomarkers requires the complementary power of professional study planning and execution modern profiling technologies and related bioinformatics tools for data analysis and interpretation. Biomarkers have considerable impact on the care of patients and are urgently needed for advancing diagnostics prognostics and treatment of disease. This survey article highlights emerging bioinformatics methods for biomarker discovery in clinical metabolomics focusing on the problem of data preprocessing and consolidation the data-driven search verification prioritization and biological interpretation of putative metabolic candidate biomarkers in disease. In particular data mining tools suitable for the application to omic data gathered from most frequently-used type of experimental designs such as case-control or longitudinal biomarker cohort studies are reviewed and case examples of selected discovery steps are delineated in more detail. This review demonstrates that clinical bioinformatics has evolved into an essential element of biomarker discovery translating new innovations and successes in profiling technologies and bioinformatics to clinical application. Biomarkers profiling technologies and bioinformatics By definition biomarkers are objectively measured indicators of normal biological processes pathogenic processes or pharmacological responses to a therapeutic intervention and . are intended to substitute for a clinical endpoint predict benefit or harm based on epidemiological therapeutic pathophysiological or other scientific evidence Biomarkers Definitions Working Group 2001 and have a variety of functions 1 . From .