tailieunhanh - báo cáo hóa học: " Results of five-year systematic screening for latent tuberculosis infection in healthcare workers in Portugal"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Results of five-year systematic screening for latent tuberculosis infection in healthcare workers in Portugal | Torres Costa et al. Journal of Occupational Medicine and Toxicology 2010 5 22 http content 571 22 JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY RESEARCH Open Access Results of five-year systematic screening for latent tuberculosis infection in healthcare workers in Portugal 1 4 5 José Torres Costa Rui Silva 1 Raul Sá Maria João Cardoso Albert Nienhaus Abstract Introduction The risk of tuberculosis TB in healthcare workers HCWs is related to its incidence in the general population and increased by the specific risk as a professional group. The prevalence of latent tuberculosis infection LTBI in HCWs in Portugal using the tuberculin skin test TST and the interferon-g release assays IGRA was analyzed over a five-year period. Methods A screening programme for LTBI in HCWs was conducted with clinical evaluations TST IGRA and chest radiography. Putative risk factors for LTBI were assessed by a standardised questionnaire. Results Between September 2005 and June 2009 5 414 HCWs were screened. The prevalence of LTBI was and using a TST 10 mm or an IGRA test result QuantiFERON-TB Gold In-Tube INF-g IU mL as a criterion for LTBI respectively. In 53 HCWs active TB was diagnosed. The number of HCWs with newly detected active TB decreased from 19 in the first year to 6 in 2008. Risk assessment was poorly related to TST diameter. However physicians and nurses had the highest rates of active TB. Conclusions LTBI and TB burden among HCWs in Portugal is high. The screening of these professionals to identify HCWs with LTBI is essential in order to offer preventive chemotherapy to those with a high risk of future progression to disease. Systematic screening had a positive impact on the rate of active TB in HCWs either by early case detection or by increasing the awareness of HCWs and therefore the precautions taken by them. Introduction With the advent of antibiotics many infectious diseases such as tuberculosis TB seemed well .