tailieunhanh - Báo cáo y học: "Safety and Effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dosedependent, phase IV clinical trial."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Safety and Effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dosedependent, phase IV clinical trial. | Jimenez et al. Journal of Cardiothoracic Surgery 2011 6 138 http content 6 1 138 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Safety and Effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients a randomized double-blind dosedependent phase IV clinical trial 1 1 1 2 1 3 Juan J Jimenez José L Iribarren Maitane Brouard Domingo Hernandez Salome Palmero Alejandro Jimenez I Qrin rhC 1 I tirantci1 k mhcidn4 II DH M Rnrrom IQIY I5 Ir icZ l i D 24 Ra friv K i ri in5 RmcTìlÍTì DÓKC171 Leonardo Loiente Patricia Machado Juan M Boiiegueio José M Raya Beatiiz Maitín Rosalía Péiez Rafael Martinez6 and María L Mora1 Abstract Background In cardiopulmonary bypass CPB patients fibrinolysis may enhance postoperative inflammatory response. We aimed to determine whether an additional postoperative dose of antifibrinolytic tranexamic acid TA reduced CPB-mediated inflammatory response IR . Methods We performed a randomized double-blind dose-dependent parallel-groups study of elective CPB patients receiving TA. Patients were randomly assigned to either the single-dose group 40 mg Kg TA before CPB and placebo after CPB or the double-dose group 40 mg Kg TA before and after CPB . Results 160 patients were included 80 in each group. The incident rate of IR was significantly lower in the double-dose-group TA2 vs. in the single-dose group TA1 P . After adjusting for hypertension total protamine dose and temperature after CPB TA2 showed a lower risk of IR compared with TA1 OR 95 CI P . Relative risk for IR was for TA1 95 CI to . The double-dose group had significantly lower chest tube bleeding at 24 hours 671 95 CI 549-793 vs. 826 95 CI 704-949 mL P corrected-P significant and lower D-dimer levels at 24 hours 489 95 CI 437-540 vs. 621 95 CI 563-679 ng mL P corrected-P significant . TA2 required lower levels