tailieunhanh - Báo cáo y học: " Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Efficacy and hypnotic effects of melatonin in shift-work nurses: double-blind, placebo-controlled crossover trial. | Journal of Circadian Rhythms BioMed Central Research Efficacy and hypnotic effects of melatonin in shift-work nurses double-blind placebo-controlled crossover trial Khosro Sadeghniiat-Haghighi Omid Aminian Gholamreza Pouryaghoub and Zohreh Yazdi Open Access Address Baharloo Hospital Tehran University of Medical Sciences Tehran Iran Email Khosro Sadeghniiat-Haghighi - sadeghniiat@ Omid Aminian - oaminian@ Gholamreza Pouryaghoub - pourya@ Zohreh Yazdi - zohrehyazdi@ Corresponding author Published 29 October 2008 Received 20 September 2008 Journal of Circadian Rhythms 2008 6 10 doi 1740-3391-6-10 Accepted 29 October 2008 This article is available from http content 6 1 10 2008 Sadeghniiat-Haghighi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Night work is associated with disturbed sleep and wakefulness particularly in relation to the night shift. Circadian rhythm sleep disorders are characterized by complaints of insomnia and excessive daytime sleepiness that are primarily due to alterations in the internal circadian timing system or a misalignment between the timing of sleep and the 24-h social and physical environment. Methods We evaluated the effect of oral intake of 5 mg melatonin taken 30 minutes before night time sleep on insomnia parameters as well as subjective sleep onset latency number of awakenings and duration of sleep. A double-blind randomized placebo-controlled crossover study with periods of I night and washouts of 4 days comparing melatonin with placebo tablets was conducted. We tried to improve night-time sleep during recovery .