tailieunhanh - Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium. | Journal of Circadian Rhythms BioMed Central Research Open Access Glycogen synthase kinase 3 circadian rhythms and bipolar disorder a molecular link in the therapeutic action of lithium Sevag A Kaladchibachi1 Brad Doble2 Norman Anthopoulos1 James R Woodgett3 and Armen S Manoukian 1 Address 1Division of Signaling Biology Ontario Cancer Institute University Health Network 610 University Avenue Toronto Ont. M5G 2M9 Canada 2Stem Cell and Cancer Research Institute McMaster University 1200 Main Street West Hamilton Ont. L8N 3Z5 Canada and 3Samuel Lunenfeld Research Institute 600 University Avenue Toronto Ont. M5G 1X5 Canada Email Sevag A Kaladchibachi - 96kaladc@ Brad Doble - dobleb@ Norman Anthopoulos - nanthopo@ James R Woodgett - woodgett@ Armen S Manoukian - armenm@ Corresponding author Published 12 February 2007 Received 13 December 2006 __ A . n. . f I loz n-A A Accepted 12 February 2007 Journal of Circadian Rhythms 2007 5 3 doi l 740-3391-5-3 This article is available from http content 5 1 3 2007 Kaladchibachi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Bipolar disorder BPD is a widespread condition characterized by recurring states of mania and depression. Lithium a direct inhibitor of glycogen synthase kinase 3 GSK3 activity and a mainstay in BPD therapeutics has been proposed to target GSK3 as a mechanism of mood stabilization. In addition to mood imbalances patients with BPD often suffer from circadian disturbances. GSK3 an essential kinase with widespread roles in development cell survival and metabolism has been demonstrated to be an essential component of the .