tailieunhanh - Báo cáo y học: "Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light. | BioMed Central Journal of Circadian Rhythms Research Open Access Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light Jacopo Aguzzi1 2 Nicole M Bullock1 and Gianluca Tosini 1 Address 1Neuroscience Institute and NSF Center for Behavioral Neuroscience Morehouse School of Medicine Atlanta GA 30310-1495 USA and 2Instituto de Ciencias del Mar ICM-CSIC Paseo Maritimo de la Barcelonesa 37-49 08003 Barcelona Spain Email Jacopo Aguzzi - jaguzzi@ Nicole M Bullock - nicolebullock@ GianlucaTosini - gtosini@ Corresponding author Published 04 April 2006 Received 01 April 2006 Journal of Circadian Rhythms2006 4 6 doi 1740-3391-4-6 Accepted 04 Apnl 2006 This article is available from http content 4 1 6 2006Aguzzi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We have recently reported that spontaneous internal desynchronization between the locomotor activity rhythm and the melatonin rhythm may occur in rats 30 of tested animals when they are maintained in constant dim red light LLdim for 60 days. Previous work has also shown that melatonin plays an important role in the modulation of the circadian rhythms of running wheel activity Rw and body temperature Tb . The aim of the present study was to investigate the effect that desynchronization of the melatonin rhythm may have on the coupling and expression of circadian rhythms in Rw and Tb. Methods Rats were maintained in a temperature controlled 23-24 C ventilated lightproof room under LLdim red dim light 1 pW cm2 5 Lux lower wavelength cutoff at 640 nm . Animals were individually housed in cages .