tailieunhanh - Báo cáo y học: "Subcoronary versus supracoronary aortic stenosis. an experimental evaluation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Subcoronary versus supracoronary aortic stenosis. an experimental evaluation. | Sorensen et al. Journal of Cardiothoracic Surgery 2011 6 100 http content 6 1 100 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Subcoronary versus supracoronary aortic stenosis. an experimental evaluation Mette Sorensen1 23 J Michael Hasenkam2 3 3 Henrik Jensen2 33 and Erik Sloth1 33 Abstract Background Valvular aortic stenosis is the most common cause of left ventricular hypertrophy due to gradually increasing pressure work. As the stenosis develop the left ventricular hypertrophy may lead to congestive heart failure increased risk of perioperative complications and also increased risk of sudden death. A functional porcine model imitating the pathophysiological nature of valvular aortic stenosis is very much sought after in order to study the geometrical and pathophysiological changes of the left ventricle timing of surgery and also pharmacological therapy in this patient group. Earlier we developed a porcine model for aortic stenosis based on supracoronary aortic banding this model may not completely imitate the pathophysiological changes that occurs when valvular aortic stenosis is present including the coronary blood flow. It would therefore be desirable to optimize this model according to the localization of the stenosis. Methods In 20 kg pigs subcoronary n 8 supracoronary aortic banding n 8 or sham operation n 4 was preformed via a left lateral thoracotomy. The primary endpoint was left ventricular wall thickness secondary endpoints were heart body weight ratio and the systolic diastolic blood flow ratio in the left anterior descending coronary. Statistical evaluation by oneway anova and unpaired t-test. Results Sub- and supracoronary banding induce an equal degree of left ventricular hypertrophy compared with the control group. The coronary blood flow ratio was slightly but not significantly higher in the supracoronary group ratio compared with the two other groups subcoronary ratio control ratio