tailieunhanh - Báo cáo y học: "Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass. | Sun et al. Journal of Cardiothoracic Surgery 2011 6 99 http content 6 1 99 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Effect of short-acting beta blocker on the cardiac recovery after cardiopulmonary bypass Jie Sun Zhengnian Ding and Yanning Qian Abstract The objective of this study was to investigate the effect of beta blocker on cardiac recovery and rhythm during cardiac surgeries. Sixty surgical rheumatic heart disease patients were received esmolol 1 mg kg or the same volume of saline prior to removal of the aortic clamp. The incidence of cardiac automatic re-beat ventricular fibrillation after reperfusion the heart rate after steady re-beat vasoactive drug use during weaning from bypass the posterior parallel time and total bypass time were decreased by esmolol treatment. In conclusion Esmolol has a positive effect on the cardiac recovery in cardiopulmonary bypass surgeries. Keywords Esmolol cardiopulmonary bypass Mitral valve replacement heart rate arrhythmia Background It has been well documented that early administration of beta-adrenergic antagonist during CPB or within 10 minutes after releasing of aortic clamp contributes to left ventricular function 1 2 . Also cardioplegia contained esmolol an ultra-short acting 9-minute half-life cardioselective beta blocker 3 has cardioprotection in animal model and clinical patients 4-7 . However few studies have investigated beta-adrenergic antagonist on the details of the cardiac recovery and rhythm during CPB. In this study we therefore investigated the effect of esmolol on the cardiac recovery in rheumatic heart surgeries. Methods The study protocol followed the Declaration of Helsinki and was approved by the Ethics and Research Committee of Nanjing Medical University Nanjing . China . The study was performed in a prospective randomized manner after all the patients signed written informed consents. 60 rheumatic heart disease patients undergoing elective .