tailieunhanh - Báo cáo y học: " Intermittent long-wavelength red light increases the period of daily locomotor activity in mice"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Intermittent long-wavelength red light increases the period of daily locomotor activity in mice. | Journal of Circadian Rhythms BioMed Central Research Open Access Intermittent long-wavelength red light increases the period of daily locomotor activity in mice John R Hofstetter 1 Amelia R Hofstetter2 Amanda M Hughes3 and Aimee R Mayeda1 Address 1Roudebush VA Medical Center 1481 W. 10th St. Indianapolis IN 46202 USA 2Berry College . Box 491640 Mt. Berry GA 301491640 USA and 3Richmond-upon-Thames College Egerton Road Twickenham Middlesex UK Email John R Hofstetter - jhofstet@ Amelia R Hofstetter - thayli21@ Amanda M Hughes - telltale_eyes@ Aimee R Mayeda - amayeda@ Corresponding author Published 31 May 2005 Received 28 March 2005 Journal of Circadian Rhythms 2005 3 8 doi l740-339l-3-8 Accepted 31 May 2005 This article is available from http content 3 l 8 2005 Hofstetter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We observed that a dim red light-emitting diode LED triggered by activity increased the circadian periods of lab mice compared to constant darkness. It is known that the circadian period of rats increases when vigorous wheel-running triggers full-spectrum lighting however spectral sensitivity of photoreceptors in mice suggests little or no response to red light. Thus we decided to test the following hypotheses dim red light illumination triggered by activity LEDfb increases the circadian period of mice compared to constant dark DD covering the LED prevents the effect on period and DBA2 J mice have a different response to LEDfb than C57BL6 J mice. Methods The irradiance spectra of the LEDs were determined by spectrophotometer. Locomotor activity of C57BL 6J and DBA 2J mice was monitored by passive-infrared .