tailieunhanh - Báo cáo y học: "Daily rhythms in plasma levels of homocysteine"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Daily rhythms in plasma levels of homocysteine. | Journal of Circadian Rhythms BioMed Central Research Daily rhythms in plasma levels of homocysteine Lena Lavie and Peretz Lavie Open Access Address Unit of Anatomy and Cell Biology Bruce Rappaport Faculty of Medicine Technion-Israel Institute of Technology Haifa 31096 Israel Email Lena Lavie - lenal@ Peretz Lavie - plavie@ Corresponding author Published 03 September 2004 Received 24 April 2004 Accepted 03 September 2004 Journal of Circadian Rhythms 2004 2 5 doi 1740-3391-2-5 This article is available from http content 2 1 5 2004 Lavie and Lavie licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background There is accumulated evidence that plasma concentration of the sulfur-containing amino-acid homocysteine Hcy is a prognostic marker for cardiovascular morbidity and mortality. Both fasting levels of Hcy and post methionine loading levels are used as prognostic markers. The aim of the present study was to investigate the existence of a daily rhythm in plasma Hcy under strictly controlled nutritional and sleep-wake conditions. We also investigated if the time during which methionine loading is performed . morning or evening had a different effect on the resultant plasma Hcy concentration. Methods Six healthy men aged 23-26 years participated in 4 experiments. In the first and second experiments the daily rhythm in Hcy as well as in other amino acids was investigated under a normal or an inverse sleep-wake cycle. In the third and fourth Hcy concentrations were investigated after a morning and evening methionine loading. To standardize food consumption in the first two experiments subjects received every 3 hours 150 ml of specially designed .