tailieunhanh - Báo cáo y học: "Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations. | Mazzoccoli et al. Journal of Circadian Rhythms 2010 8 6 http content 8 1 6 RESEARCH JOURNAL OF CIRCADIAN RHYTHMS Open Access Aging related changes of circadian rhythmicity of cytotoxic lymphocyte subpopulations Gianluigi Mazzoccoli 1 Angelo De Cata1 Antonio Greco1 Marcello Damato1 Nunzia Marzulli1 Mariangela Pia Dagostino1 Stefano Carughi1 Federico Perfetto2 and Roberto Tarquini2 Abstract Background Immunosenescence is a process that affects all cell compartments of the immune system and the contribution of the immune system to healthy aging and longevity is still an open question. Lymphocyte subpopulations present different patterns of circadian variation and in the elderly alteration of circadian rhythmicity has been evidenced. The aim of our study was to analyze the dynamics of variation of specific cytotoxic lymphocyte subsets in old aged subjects. Methods Lymphocyte subpopulation analyses were performed and cortisol serum levels were measured on blood samples collected every four hours for 24 hours from fifteen healthy male young-middle aged subjects age range 3655 years and fifteen healthy male old aged subjects age range 67-79 years . Results In healthy young-middle aged subjects CD20 were higher and at 06 00 h CD8 dim correlated positively with CD16 and positively with ỴỖTCR cells CD16 correlated positively with ỴỖTCR cells At 18 00 h CD8 dim correlated positively with CD16 and positively with ỴỖTCR cells CD16 correlated positively with ỴỖTCR cells and a clear circadian rhythm was validated for the time-qualified changes of CD3 CD4 CD20 CD25 and HLA-DR cells with acrophase during the night and for the time-qualified changes of CD8 CD8 bright CD8 dim CD16 and ỴỖTCR cells with acrophase during the day. In old aged subjects CD25 DR T cells and cortisol serum levels were higher but there was no statistically significant correlation among lymphocyte subpopulations and a clear circadian rhythm was evidenced for time-qualified changes of

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