tailieunhanh - Báo cáo y học: "Chronotypology and melatonin alterations in minimal hepatic encephalopathy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Chronotypology and melatonin alterations in minimal hepatic encephalopathy. | Journal of Circadian Rhythms BioMed Central Research Chronotypology and melatonin alterations in minimal hepatic encephalopathy Dimitrios Velissaris 1 Vasilis Karamouzos1 Panagiotis Polychronopoulos2 and Menelaos Karanikolas1 Open Access Address Department of Anaesthesiology and Critical Care Medicine Patras University Hospital Rion 26500 Greece and 2Department of Neurology Patras University Hospital Rion 26500 Greece Email Dimitrios Velissaris - dimitrisvelissaris@ Vasilis Karamouzos - vkaramouzos@ Panagiotis Polychronopoulos - ppolychr@ Menelaos Karanikolas - kmenelaos@ Corresponding author Published 29 May 2009 Received 22 February 2009 Journal ofCircadian Rhythms 2009 7 6 doi 1740-3391-7-6 Accepted 29 May 2009 This article is available from http content 7 1 6 2009 Velissaris et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Minimal subclinical hepatic encephalopathy is a term that describes impairment of every day life activities in cirrhosis patients without clinical neurologic abnormalities. Melatonin diurnal pattern disruption and metabolic changes due to liver insufficiency can affect the human biologic clock. Our study was conducted to measure plasma melatonin levels in an attempt to correlate plasma melatonin abnormalities with liver insufficiency severity and describe chronotypology in cirrhosis patients with minimal encephalopathy. Methods Twenty-six cirrhotic patients enrolled in the study and thirteen patients without liver or central nervous system disease served as controls. All patients had full clinical and biochemical evaluation chronotypology analysis neurological evaluation melatonin profile and quality of .