tailieunhanh - báo cáo hóa học: " Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells | Journal of Neuroinflammation BioMed Central Research Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid p-protein in cerebrovascular smooth muscle cells Mary Lou Previti Weibing Zhang and William E Van Nostrand Open Access Address Department of Medicine Health Sciences Center Stony Brook University Stony Brook NY 11794-8153 USA Email Mary Lou Previti - Weibing Zhang - William E Van Nostrand - Corresponding author Published 03 August 2006 Received 03 April 2006 Journal of Neuroinflammation 2006 3 18 doi 1742-2094-3-18 Accepted 03 August 2006 This article is available from http content 3 1 18 2006 Previti et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cerebrovascular deposition of fibrillar amyloid P-protein AP a condition known as cerebral amyloid angiopathy CAA is a prominent pathological feature of Alzheimer s disease AD and related disorders. Accumulation of cerebral vascular fibrillar Ap is implicated in promoting local neuroinflammation causes marked degeneration of smooth muscle cells and can lead to loss of vessel wall integrity with hemorrhage. However the relationship between cerebral vascular fibrillar AP-induced inflammatory responses and localized cytotoxicity in the vessel wall remains unclear. Steroidal-based anti-inflammatory agents such as dexamethasone have been reported to reduce neuroinflammation and hemorrhage associated with CAA. Nevertheless the basis for the beneficial effects of steroidal anti-inflammatory drug treatment with respect to local inflammation and hemorrhage in CAA is unknown. The cultured human cerebrovascular