tailieunhanh - báo cáo hóa học: " Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy | Journal of Neuroinflammation BioMed Central Open Access Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Ap immunotherapy Pritam Das Lisa A Smithson Robert W Price Vallie M Holloway Yona Levites Paramita Chakrabarty and Todd E Golde Address Department of Neurosciences Mayo Clinic College of Medicine 4500 San Pablo Road Jacksonville FL 32224 USA Email Pritam Das Vallie M Holloway - Yona Levites - Paramita Chakrabarty - Todd E Golde - Corresponding authors Published 26 July 2006 Received 13 March 2006 Journal of Neuroinflammation 2006 3 17 doi 1742-2094-3-17 Accepted 26 July 2006 This article is available from http content 3 1 17 2006 Das et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Microglial activation has been proposed to facilitate clearance of amyloid p protein AP from the brain following Ap immunotherapy in amyloid precursor protein APP transgenic mice. Interleukin-1 receptor 1 knockout IL-1 R1- - mice are reported to exhibit blunted inflammatory responses to injury. To further define the role of IL-1-mediated inflammatory responses and microglial activation in this paradigm we examined the efficacy of passive Ap immunotherapy in Tg2576 mice crossed into the IL-1 R1- - background. In addition we examined if loss of IL-1 R1- - modifies Ap deposition in the absence of additional manipulations. Methods We passively immunized Tg2576 mice crossed into the IL-1 R1- - background APP IL-1 R1- - mice with .