tailieunhanh - báo cáo hóa học: " Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury | Journal of Neuroinflammation BioMed Central Research Open Access Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury Hsiao-Wen Lint1 Anirban Basut2 Charles Druckman3 Michael Cicchese3 J Kyle Krady3 and Steven W Levison 1 Address department of Neurology and Neuroscience UMDNJ-New Jersey Medical School Newark NJ 07103 USA 2National Brain Research Centre Gurgaon - 122 050 India and 3Dept. of Neural and Behavioral Sciences The Pennsylvania State University College of Medicine Hershey PA 17033 UsA Email Hsiao-Wen Lin - linh3@ Anirban Basu - anirban@ Charles Druckman - chuckdruck@ Michael Cicchese - michael_cicchese@ J Kyle Krady- jkk7@ StevenW Levison - Corresponding author tEqual contributors Published 30 June 2006 Received 23 February 2006 Journal of Neuroinflammation 2006 3 15 doi 1742-2094-3-15 Accepted 30 June 2006 This article is available from http content 3 1 15 2006 Lin et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The cytokines IL-la and IL-lp are induced rapidly after insults to the CNS and their subsequent signaling through the type l IL-l receptor IL-lRl has been regarded as essential for a normal astroglial and microglial macrophage response. To determine whether abrogating signaling through the IL-lRl will alter the cardinal astrocytic responses to injury we analyzed molecules characteristic of activated astrocytes in response to a penetrating stab wound in wild type mice and mice with a targeted deletion of IL-lRl. Here we show that after a stab wound injury glial fibrillary acidic protein GFAP induction on a per cell basis is delayed in the