tailieunhanh - báo cáo hóa học: " Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice | Journal of Neuroinflammation BioMed Central Research Open Access Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP V717I transgenic mice Michael T Heneka 1 Magdalena Sastre2 Lucia Dumitrescu-Ozimek2 Ilse Dewachter3 Jochen Walter2 Thomas Klockgether2 and Fred Van Leuven3 Address Department of Neurology University of Munster 48149 Munster Germany 2Department of Neurology University of Bonn 53127 Bonn Germany and 3Experimental Genetics Group Dept Human Genetics B-3000 Leuven Belgium Email Michael T Heneka - heneka@ Magdalena Sastre - Lucia Dumitrescu- Ozimek - Ilse Dewachter - Jochen Walter - Thomas Klockgether - klockgether@ Fred Van Leuven - fredVL@ Corresponding author Published 07 October 2005 Received 02 May 2005 Journal ofNeuroinflammation 2005 2 22 doi 1742-2094-2-22 Accepted 07 October 2005 This article is available from http content 2 1 22 2005 Heneka et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation is suspected to contribute to the progression and severity of neurodegeneration in Alzheimer s disease AD . Transgenic mice overexpressing the london mutant of amyloid precursor protein APP V717I robustly recapitulate the amyloid pathology of AD. Methods Early and late temporal and spatial characteristics of inflammation were studied in APP V717I mice at 3 and 16 month of age. Glial activation and expression of inflammatory markers were determined by immunohistochemistry and RT-PCR. Amyloid deposition was .