tailieunhanh - báo cáo hóa học: " Microglial responses to amyloid β peptide opsonization and indomethacin treatment"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Microglial responses to amyloid β peptide opsonization and indomethacin treatment | Journal of Neuroinflammation BioMed Central Research Open Access Microglial responses to amyloid p peptide opsonization and indomethacin treatment Ronald Strohmeyer Carl J Kovelowski Diego Mastroeni Brian Leonard Andrew Grover and Joseph Rogers Address . Roberts Center Sun Health Research Institute 10515 West Santa Fe Drive Sun City AZ 85351 USA Email Ronald Strohmeyer - RWStrohmeyer@ Carl J Kovelowski - cjkovelowski@ Diego Mastroeni - Brian Leonard - Andrew Grover - Joseph Rogers - Corresponding author Published 19 August 2005 Received 18 June 2005 Journal of Neuroinflammation 2005 2 18 doi 1742-2094-2-18 Accepted 19 August 2005 This article is available from http content 2 1 18 2005 Strohmeyer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent studies have suggested that passive or active immunization with anti-amyloid p peptide Ap antibodies may enhance microglial clearance of Ap deposits from the brain. However in a human clinical trial several patients developed secondary inflammatory responses in brain that were sufficient to halt the study. Methods We have used an in vitro culture system to model the responses of microglia derived from rapid autopsies of Alzheimer s disease patients to Ap deposits. Results Opsonization of the deposits with anti-Ap IgG 6E10 enhanced microglial chemotaxis to and phagocytosis of Ap as well as exacerbated microglial secretion of the pro-inflammatory cytokines TNF-a and IL-6. Indomethacin a common nonsteroidal anti-inflammatory drug NSAID had no effect on microglial chemotaxis or phagocytosis .