tailieunhanh - báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease | Journal of Neuroinflammation BioMed Central Research Open Access Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer s disease Nikunj S Patel Daniel Paris Venkatarajan Mathura Amita N Quadros Fiona C Crawford and Michael J Mullan Address Roskamp Institute 2040 Whitfield Avenue Sarasota FL34243 USA Email Nikunj S Patel - npatel@ Daniel Paris - dparis@ Venkatarajan Mathura - vmathura@ Amita N Quadros - aquadros@ Fiona C Crawford - fcrawford@ Michael J Mullan - mmullan@ Corresponding author Published II March 2005 Received 17 January 2005 Journal of Neuroinflammation 2005 2 9 doi 186 1742-2094-2-9 Accepted I I March 2005 This article is available from http content 2 1 9 2005 Patel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Inflammation is believed to play an important role in the pathology of Alzheimer s disease AD and cytokine production is a key pathologic event in the progression of inflammatory cascades. The current study characterizes the cytokine expression profile in the brain of two transgenic mouse models of AD TgAPPsw and PS1 APPsw and explores the correlations between cytokine production and the level of soluble and insoluble forms of Ap. Methods Organotypic brain slice cultures from 15-month-old mice TgAPPsw PS1 APPsw and control littermates were established and multiple cytokine levels were analyzed using the Bio-plex multiple cytokine assay system. Soluble and insoluble forms of Ap were quantified and Ap-cytokine relationships were analyzed. Results Compared to control littermates transgenic mice showed a significant increase in the following pro-inflammatory