tailieunhanh - báo cáo hóa học: " Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? | Journal of Neuroinflammation BioMed Central Research Open Access Does angiotensin-l converting enzyme genotype influence motor or cognitive development after pre-term birth David R Harding 1 Sukhbir Dhamrait2 David Devadason1 Steve E Humphries2 Andrew Whitelaw3 Neil Marlow4 and Hugh E Montgomery2 Address 1Neonatal Intensive Care Unit St. Michael s Hospital Bristol UK 2Division of Cardiovascular Genetics University College London London UK 3University of Bristol Medical School Southmead Hospital Bristol UK and 4School of Human Development University of Nottingham Nottingham UK Email David R Harding - Sukhbir Dhamrait - David Devadason - daviddevadason@ Steve E Humphries - rmhaseh@ Andrew Whitelaw - Neil Marlow - Hugh E Montgomery - rmhahum@ Corresponding author Published 22 February 2005 Received 22 November 2004 Journal ofNeuroinflammation 2005 2 6 doi l 742-2094-2-6 Accepted 22 February 2005 This article is available from http content 2 1 6 2005 Harding et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Raised activity of the renin-angiotensin system RAS may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant. The angiotensin-converting enzyme ACE DD genotype is associated with raised ACE and RAS activity as well as potentially adverse stimuli such as inflammation. The DD genotype has been associated with neurological impairments in the elderly and thus may be also associated with poorer motor or cognitive development amongst children .