tailieunhanh - báo cáo hóa học: " Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults | Journal of Neuroinflammation BioMed Central Research Open Access Infiltrative microgliosis activation and long-distance migration of subependymal microglia following periventricular insults W Shawn Carbonell1 2 Shin-Ichi Murase3 Alan F Horwitz2 3 and James W Mandell 2 4 Address 1Medical Scientist Training Program University of Virginia Charlottesville Virginia 22908 USA 2Neuroscience Graduate Program University of Virginia Charlottesville Virginia 22908 USA 3Department of Cell Biology University of Virginia Charlottesville Virginia 22908 USA and 4Department of Pathology Division of Neuropathology University of Virginia Charlottesville Virginia 22908 USA Email W Shawn Carbonell - bigaxon@ Shin-Ichi Murase - sm4fh@ Alan F Horwitz - horwitz@ James W Mandell - jim_mandell@ Corresponding author Published 28 January 2005 Received 29 December 2004 Journal of Neuroinflammation 2005 2 5 doi 1742-2094-2-5 Accepted 28 January 2005 This article is available from http content 2 1 5 2005 Carbonell et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Subventricular microglia SVMs are positioned at the interface of the cerebrospinal fluid and brain parenchyma and may play a role in periventricular inflammatory reactions. However SVMs have not been previously investigated in detail due to the lack of a specific methodology for their study exclusive of deeper parenchymal microglia. Methods We have developed and characterized a novel model for the investigation of subventricular microglial reactions in mice using intracerebroventricular ICV injection of high-dose rhodamine dyes. Dynamic studies using timelapse confocal microscopy in situ .